Abnormal Activity of Primary Somatosensory Cortex in Central Pain Syndrome
نویسندگان
چکیده
منابع مشابه
Abnormal activity of primary somatosensory cortex in central pain syndrome.
Central pain syndrome (CPS) is a debilitating and chronic pain condition that results from a lesion or dysfunction in the CNS. The pathophysiological mechanisms underlying CPS are poorly understood. We recently demonstrated that CPS is associated with suppressed inputs from the inhibitory nucleus zona incerta to the posterior thalamus (PO). As a consequence, activity in PO is abnormally increas...
متن کامل1 Abnormal Activity of Primary Somatosensory Cortex in Central Pain Syndrome 2 3
(1) Program in Neuroscience, (2) Department of Anatomy & Neurobiology, University of 5 Maryland School of Medicine, (3) Department of Endodontics, Prosthodontics and Operative 6 Dentistry, University of Maryland Baltimore College of Dental Surgery, (4) Department of 7 Physiology, University of Maryland School of Medicine. Baltimore, MD 21201. 8 9 10 Running head: Abnormal Activity of Somatosens...
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Although each subdivision of primary somatosensory cortex (SI) receives dense input from the thalamus, but the exact location and type of information that the fibers convey have not been identified yet. In the present study, the exact source of thalamocortical fibers to areas 2 and 3b was investigated using tract-tracing techniques. Following injection of tracer into area 3b, labeled neurons ...
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Central pain syndrome (CPS) is a debilitating condition that affects a large number of patients with a primary lesion or dysfunction in the CNS, most commonly due to spinal cord injury, stroke, and multiple sclerosis lesions. The pathophysiological processes underlying the development and maintenance of CPS are poorly understood. We have recently shown, in an animal model of CPS, that neurons i...
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The intensity and submodality of pain are widely attributed to stimulus encoding by peripheral and subcortical spinal/trigeminal portions of the somatosensory nervous system. Consistent with this interpretation are studies of surgically anesthetized animals, demonstrating that relationships between nociceptive stimulation and activation of neurons are similar at subcortical levels of somatosens...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2010
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00161.2010